Significance of CH/ Interactions on the Stability of Therapeutic Proteins
نویسندگان
چکیده
A computational analysis on the CH/ interactions in a group of 49 therapeutic proteins was investigated. A total of 77 CH/ interactions were observed. The donor atom contribution to CH/ interactions was mainly from aromatic residues. Long-range CH/ interactions are the predominant type of interactions in therapeutic proteins data set. The secondary structure preference, solvent accessibility and stabilization centers of these of CH/ interacting residues were estimated. 73% of the donor residues and 65% of the acceptor residues were highly conserved.
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تاریخ انتشار 2009